synthetic canonical mir-31 , a pleiotropically acting anti-metastasis mir-based therapeutic in invasive breast cancer
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A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
Scott Valastyan,1,2 Ferenc Reinhardt,1 Nathan Benaich,1,3 Diana Calogrias,4 Attila M. Szász,4 Zhigang C. Wang,5,6 Jane E. Brock,4 Andrea L. Richardson,4 and Robert A. Weinberg1,2,7,* 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 3Department of Biology, Williams College, Williamstown,...
full textRetraction Notice to: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
MicroRNAs are well suited to regulate tumor metastasis because of their capacity to coordinately repress numerous target genes, thereby potentially enabling their intervention at multiple steps of the invasion-metastasis cascade. We identify a microRNA exemplifying these attributes, miR-31, whose expression correlates inversely with metastasis in human breast cancer patients. Overexpression of ...
full textInhibition of breast cancer metastasis by co-transfection of miR-31/193b-mimics
Objective(s): Various studies have been conducted to reduce the metastatic behavior of cancerous cells. In this regard, ectopic expression of anti-metastatic microRNAs by miR-mimic and miR-restoration-based therapies could bring new insights to the field. In the present study, the consequences of co-transfecting breast cancer cell lines with miR-193b and miR-31 were investigated via invasion an...
full textاستفاده از miR-31-mimic جهت مهار متاستاز سرطان پستان در رده سلولی MDA-MB231 غنی از سلولهای بنیادی سرطانی
Background: Metastasis associated miRNA (metastamiR) opened a new field of anti-metastatic therapy which have a great potential of treatment for the most lethal aspect of cancer, metastasis. The pleiotropic nature of gene regulation exhibited by certain miRNAs that showed that miRNAs might be endowed with a capacity to function as crucial modulators of tumor metastasis. MiR-31 is a pleiotropic ...
full textMetastasis inhibition by BRMS1 and miR-31 replacement therapy in claudin-low cell lines
Objective(s): The growing trend of research demonstrates that dynamic expression of two metastasis repressor classes (metastasis suppressor genes and anti-metastatic miRNA) has a close relationship with tumor invasion and metastasis. Using different strategies, it was revealed that cellular levels of miR-31 and Breast cancer Metastasis Suppressor1 (BRMS1) protein, whic...
full textBreast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis.
Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that differentially regulates expression of multiple genes, leading to suppression of metastasis without blocking orthotopic tumor growth in multiple human and murine cancer cells of diverse origins. We hypothesized that miR-146 may be involved in the ability of BRMS1 to supress metastasis because miR-146 expressio...
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research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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